Roberto Docampo Selected Research

Polyphosphates

12/2021	The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions.
1/2021	Ca2+ entry at the plasma membrane and uptake by acidic stores is regulated by the activity of the V-H+ -ATPase in Toxoplasma gondii.
1/2021	The IP3 receptor and Ca2+ signaling in trypanosomes.
1/2020	Isolation and Characterization of Acidocalcisomes from Trypanosomatids.
1/2019	The acidocalcisome inositol-1,4,5-trisphosphate receptor of Trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products.
1/2019	Pyrophosphate Stimulates the Phosphate-Sodium Symporter of Trypanosoma brucei Acidocalcisomes and Saccharomyces cerevisiae Vacuoles.
1/2019	NUDIX hydrolases with inorganic polyphosphate exo- and endopolyphosphatase activities in the glycosome, cytosol and nucleus of Trypanosoma brucei.
12/2018	5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles.
12/2018	Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids.
9/2016	The origin and evolution of the acidocalcisome and its interactions with other organelles.

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Roberto Docampo Research Topics

Disease

43	Chagas Disease (American Trypanosomiasis) 01/2022 - 08/2002
23	Polyps 12/2021 - 12/2002
10	Bone Resorption 01/2019 - 07/2002
9	Toxoplasmosis 01/2019 - 09/2007
8	Infections 12/2020 - 02/2002
5	Starvation 12/2021 - 01/2004
5	African Trypanosomiasis (Nagana) 01/2019 - 06/2003
5	Parasitic Diseases (Parasitic Disease) 06/2015 - 12/2010
4	Malaria 01/2016 - 01/2004
2	Cutaneous Leishmaniasis 01/2020 - 07/2002
2	Inflammation (Inflammations) 01/2016 - 04/2010
2	Neglected Diseases 01/2016 - 05/2014
1	Osteoporosis 01/2020
1	Bone Diseases (Bone Disease) 01/2018
1	Cryptosporidiosis 01/2016
1	Leishmaniasis 01/2016
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 04/2015
1	Hemorrhage 11/2014
1	Thrombosis (Thrombus) 11/2014
1	Leukemia 08/2012
1	Lung Diseases (Lung Disease) 09/2010
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2010

Drug/Important Bio-Agent (IBA)

23	PolyphosphatesIBA 12/2021 - 12/2002
13	Diphosphonates (Bisphosphonates)IBA 01/2020 - 07/2002
11	Phosphates (Orthophosphate)IBA 12/2021 - 01/2004
9	CalciumIBA 12/2021 - 04/2010
9	diphosphoric acid (pyrophosphoric acid)IBA 01/2021 - 01/2004
7	Pharmaceutical PreparationsIBA 01/2022 - 07/2002
7	EnzymesIBA 01/2017 - 12/2002
6	Proteins (Proteins, Gene)FDA Link 10/2021 - 02/2002
6	farnesyl pyrophosphate (farnesyl diphosphate)IBA 01/2017 - 03/2004
5	CationsIBA 01/2020 - 12/2002
4	PolymersIBA 01/2021 - 11/2013
4	Antiparasitic Agents (Antiparasitics)IBA 06/2015 - 03/2004
4	4-phenoxyphenoxyethyl thiocyanateIBA 11/2013 - 08/2002
4	Risedronic Acid (Actonel)FDA LinkGeneric 12/2010 - 03/2002
3	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 12/2005
3	Protons (Proton)IBA 01/2021 - 12/2005
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 11/2013
3	mitochondrial calcium uniporterIBA 01/2019 - 01/2017
3	PyrophosphatasesIBA 09/2016 - 09/2005
3	AcidsIBA 01/2014 - 03/2008
3	Pamidronate (Aredia)FDA LinkGeneric 06/2012 - 07/2002
3	GeranyltranstransferaseIBA 04/2011 - 10/2004
2	Biological ProductsIBA 10/2021 - 01/2020
2	Phenobarbital (Luminal)FDA Link 01/2021 - 01/2019
2	SterolsIBA 01/2020 - 05/2014
2	VaccinesIBA 01/2020 - 01/2016
2	Phosphorus (Red Phosphorus)IBA 01/2020 - 01/2016
2	exopolyphosphataseIBA 01/2019 - 12/2002
2	Escherichia coli Ppx proteinIBA 12/2018 - 08/2012
2	Proton-Translocating ATPases (ATPase, H+)IBA 09/2016 - 11/2005
2	Inorganic Pyrophosphatase (Pyrophosphatase, Inorganic)IBA 09/2016 - 12/2004
2	Heparin (Liquaemin)FDA LinkGeneric 11/2014 - 12/2002
2	polyacrylamideIBA 08/2012 - 10/2004
2	DAPIIBA 08/2012 - 10/2004
2	Urea (Carbamide)FDA LinkGeneric 08/2012 - 10/2004
2	Serotonin (5 Hydroxytryptamine)IBA 08/2012 - 10/2004
2	Coordination ComplexesIBA 06/2012 - 12/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2012 - 11/2005
2	NitrogenIBA 07/2010 - 05/2003
1	Recombinant ProteinsIBA 12/2021
1	GelsIBA 12/2021
1	Histidine Ammonia-LyaseIBA 12/2021
1	Lysine (L-Lysine)FDA Link 12/2021
1	Protein Kinases (Protein Kinase)IBA 10/2021
1	Pyruvic Acid (Pyruvate)IBA 01/2021
1	Inositol PhosphatesIBA 01/2021
1	triphosphoric acid (triphosphate)IBA 01/2021
1	Ru 360IBA 12/2020
1	Ruthenium RedIBA 12/2020
1	Ru265IBA 12/2020
1	selenocyanic acid (selenocyanate)IBA 01/2019
1	Adenosine Diphosphate (ADP)IBA 01/2019
1	SymportersIBA 01/2019
1	Nudix HydrolasesIBA 01/2019
1	SodiumIBA 01/2019
1	Adenosine Monophosphate (AMP)IBA 11/2018
1	Ammonium CompoundsIBA 01/2018
1	Ergosterol (Lumisterol)IBA 12/2017
1	Mevalonic Acid (Mevalonate)IBA 12/2016
1	Proton Pumps (Proton Pump)IBA 09/2016
1	Phosphorus CompoundsIBA 09/2016
1	Phosphate Transport Proteins (Phosphate Transporter)IBA 09/2015
1	Growth InhibitorsIBA 06/2015
1	trans-sialidaseIBA 06/2014
1	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 05/2014
1	Phosphotransferases (Kinase)IBA 11/2013
1	polyphosphate kinaseIBA 11/2013
1	CoagulantsIBA 08/2012
1	Cell ExtractsIBA 08/2012
1	Immunoglobulin E (IgE)IBA 08/2012
1	Histamine (Histamine Dihydrochloride)FDA Link 08/2012
1	BradykininIBA 08/2012
1	Alendronate (Alendronate Sodium)FDA LinkGeneric 06/2012
1	MetalsIBA 12/2010
1	LigandsIBA 12/2010
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 09/2010

Therapy/Procedure

6	Drug Therapy (Chemotherapy) 02/2013 - 06/2003
4	Therapeutics 05/2014 - 07/2002